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Adrenoleucodystrophy (ALD)

Adrenoleukodystrophy (ALD) is “a rare genetic disorder characterized by the breakdown or loss of the myelin sheath surrounding nerve cells in the brain and progressive dysfunction of the adrenal gland. ALD is one of a group of genetic disorders called the leukodystrophies that cause damage to the myelin sheath of the nerve fibers in the brain. The myelin sheath is a fatty covering which acts as an electrical insulator.”

Adrenoleukodystrophy is a “childhood genetic disease, transmitted as an X-linked recessive trait, characterized by diffuse abnormality of cerebral white matter and adrenal atrophy; mental deterioration progresses to dementia, aphasia, apraxia, dysarthria and loss of vision.”

Adrenoleukodystrophy is “a syndrome combining the characteristics of adrenocortical insufficiency (Addison disease) with those of cerebral sclerosis (Schilder disease). Skin bronzing and sclerosis of the brain and demyelination are the principal manifestations.”

In vitro studies are being conducted at the Kennedy Krieger Institute; and Departments of Pediatrics and Neurology and Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.



Copies of clinical trials are available upon request for doctors and medical researchers.

 

 

 

 

 

 

DISCLAIMER:The information presented is intended for educational purposes for health professionals and practitioners, and is obtained from published research. It is not intended to be prescriptive nor to replace the care of a licensed health professional in the diagnosis and treatment of illness.
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